ABSTRACT
Traditional medicine is often considered to be a kind of complementary or alternative medicine (CAM) nowadays. Therefore, documenting and identifying the herbs that are effective in treating various diseases is vital for future disease control programs. The study aims to perform Molecular docking analysis of the phytoconstituents of the Bauhinia acuminata named Quercetin, Bauhinone, Beta-sitosterol, and Kaempferol 3-glycoside with the target proteins with PDB IDs namely 2ITY, 1A52, 3L4U, IT02, 5COX, 6VYO involved in Lung cancer, breast cancer, anti-diabetes, anti-obesity, anti-inflammatory, and SARS COV-2. Chemsketch software, the study of the in-silico docking was done using Autodock.4.2 software and the binding interactions are visualized using Discovery studio 3.1. The docking scores and analysis of the interactions of the phytoconstituents with target proteins suggests that all the selected 5 phytoconstituents showed excellent binding to 2ITY and 5-COX as opposed to the standard drugs Erlotinib and Aspirin. In this study, it was concluded that the investigated phytoconstituents showed potent inhibiting activity, and the dock scores as opposed to standard as in Table 6, directly represent possible binding to the target proteins indicating their good biological activity as in lung cancer and anti-inflammatory action.